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| Case Studies |
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| By evaluating clinical and laboratory data from actual patient
cases, these case studies represent education through experience. |
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| · Case Study #1: Acquired
FVIII Inhibitor |
| A 61-year-old man with emphysema and cancer of the head and
neck was admitted to the hospital with ecchymoses and hematomas
on the arms, legs, and back. While no overt GI bleeding was
observed, the patient's hemoglobin was 6.1 gm/dL. Coagulation
studies were performed to ascertain the cause for bleeding |
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| · Case Study #2: DVT
and Argatroban |
| A 77-year-old woman was admitted to the hospital with deep
vein thrombosis (DVT). The patient had recently been diagnosed
with heparin-induced thrombocytopenia (HIT) and as a result
was now treated with argatroban anticoagulation instead of heparin.
In order to ascertain the cause of the patient's thrombophilia,
the following laboratory tests were performed. |
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| · Case Study #3: Lupus
Anticoagulant Testing and Heparin |
| A 67 year old female with a history of rheumatic heart disease
underwent a porcine mitral valve replacement in 1981. The valve
had to be revised to a mechanical prosthetic valve in 1991 after
which she was placed on chronic warfarin therapy. In 1996, she
was admitted to the Cardiology service for consideration of
tricuspid valve replacement due to progressive valvular regurgitation
resulting in right sided heart failure. While on warfarin, the
APTT was noted to be disproportionately prolonged for the degree
of anticoagulation. |
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